In cases of suspected serious ingestion, vitamin K1 is (phytomenadione) as indicated by the prothrombin time.įresh frozen plasma or whole blood are indicated in cases ofĬlose clinical observation is essential to detect occultīleeding or life-threatening haemorrhage. Treatment is based on the administration of vitamin K1 Should be monitored closely using prothrombin time (PT) and If more than 24 hours have elapsed since ingestion,ĭecontamination measures are not effective and the patient Promptly, and should be avoided in patients who are already GastricĮmptying is not necessary if activated charcoal can be given Ingestion was recent administer activated charcoal.
Hospital for initial clinical and laboratory evaluation. The most relevant biomedical analysisĪctivated partial thromboplastin time (PTT) 2.4 First-aid measures and management principles All cases of warfarin ingestion should be taken to a 2.3 Diagnosis The diagnosis is based on history of exposure (generallyīy ingestion of a rodenticide) clinical evidence ofīleeding, which may appear 1 to 2 days post ingestion andĪ sample of the rodenticide should be kept for toxicologicalĪnalysis (if feasible). Haematomata, haematemesis, melenae, haematuria. Impaired, with gum bleeding, epistaxis, ecchymosis, 2.2 Summary of clinical effects If toxic amounts have been ingested, coagulation will be Potentially fatal gastrointestinal and intracerebral SUMMARY 2.1 Main risks and target organs The target system is the haematological system, with (R)-(+)-isomer CAS number: NIOSH RTECS GN4550000 1.5 Brand names, Trade names 1.6 Manufacturers, Importers 2.
NAME 1.1 Substance Warfarin 1.2 Group Coumarin derivative 1.3 Synonyms Coumadin Coumafene Zoocoumarin 1.4 Identification numbers 1.4.1 CAS number AUTHOR(S), REVIEWER (S), DATE (S) (INCLUDING UPDATES), COMPLETE ADDRESS (ES)ġ. TOXICOLOGICAL ANALYSES & BIOMEDICAL INVESTIGATIONSĨ.1.2 Storage of laboratory samples & specimensĨ.1.3 Transport of laboratory samples &specimensĨ.2 Toxicological Analyses and Their InterpretationĨ.2.1 Tests on toxic ingredient(s) of materialĨ.2.1.2 Advanced Qualitative Confirmation Test(s)Ĩ.2.2.2 Advanced Qualitative Confirmation Test(s)Ĩ.2.3 Interpretation of toxicological analysesĨ.3 Biomedical investigations & their interpretationĨ.3.4 Interpretation of biomedical investigationsĩ.4 Systematic description of clinical effectsĩ.4.9 Eye, ears, nose, throat: local effectsĩ.4.12.2 Fluid & electrolyte disturbancesġ4.
2.4 First-aid measures and management principlesĦ.3 Biological half-life by route of exposureħ.2.5 Acceptable daily intake (ADI) and other guideline levelsĨ.
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